{"id":9,"date":"2016-01-26T15:19:17","date_gmt":"2016-01-26T14:19:17","guid":{"rendered":"http:\/\/rainy276.valuehost.ru\/synpel.eu\/?page_id=9"},"modified":"2025-06-04T16:41:15","modified_gmt":"2025-06-04T14:41:15","slug":"%d1%82%d0%b5%d1%85%d0%bd%d0%be%d0%bb%d0%be%d0%b3%d0%b8%d0%b8","status":"publish","type":"page","link":"https:\/\/www.synpel.eu\/?page_id=9","title":{"rendered":"R&#038;D"},"content":{"rendered":"<p>Currently, the company is developing a universal method for producing peptide hormones of the insulin superfamily.<\/p>\n<p class=\"entry-title\"><a href=\"https:\/\/www.synpel.eu\/?page_id=1111\">Synthetic Insulin<\/a><\/p>\n<p class=\"entry-title\"><a href=\"https:\/\/www.synpel.eu\/?page_id=1135\">New Insulin Analog<\/a><\/p>\n<p class=\"entry-title\"><a href=\"https:\/\/www.synpel.eu\/?page_id=1148\">Synthetic insulin with boronic acid-diol switch<\/a><\/p>\n<p><a href=\"https:\/\/www.synpel.eu\/?page_id=1156\">Palmitoyl derivative of Relaxin-2<\/a><\/p>\n<p>The insulin superfamily is a large group of peptides with diverse physiological activities found throughout the animal kingdom. These peptides have a conserved structure and exhibit a wide range of biological activities, including glucose homeostasis, tissue growth, cardiovascular and reproductive processes, and others yet to be determined. To determine biological activity, a source of sufficient quantities of these peptides is necessary. Therefore, obtaining these peptides by chemical synthesis is a demanded task.<\/p>\n<p>The history of the chemical synthesis of <a href=\"http:\/\/www.synpel.eu\/wp-content\/uploads\/2024\/04\/Synthetic-Insulin.pdf\">insulin<\/a>, relaxins, and <a href=\"http:\/\/www.synpel.eu\/wp-content\/uploads\/2024\/04\/Insulin-like-Peptides-are-Now-Available-for-Large-scale-Research.pdf\">insulin-like peptides<\/a> goes back to around 60 years. Over 40 years ago, the solid-phase method was introduced, along with new reagents and protecting groups. This expansion significantly increased the possibilities for synthesis\u00a0 this family of peptides.<\/p>\n<p>Based on these advancements, we have developed an efficient scheme for the synthesis of insulin-like peptides. Our approach allows us to obtain natural insulin-like peptides and their analogs, including challenging ones for chemical synthesis such as insulin-like peptide 5 (see pictures below).<\/p>\n<p>The stability of our synthesis scheme allows us to reliably obtain multiple analogues of insulin-like peptides in small quantities (1-5 mg) sufficient for &#8220;screening research needs&#8221;. At the same time, when required, our lab production capacity allows us to scale up to 10g of individual peptide with a purity greater than 98% by HPLC.<\/p>\n<p>You can find up-to-date information on our <a href=\"linkedin.com\/company\/synpel-chemical\" target=\"_blank\" rel=\"noopener\">LinkedIn<\/a>. We hope that our capabilities in the synthesis of insulin-like peptides will be of interest to a wide range of researchers and pharmaceutical companies.<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-medium\" src=\"http:\/\/www.synpel.eu\/wp-content\/uploads\/2023\/10\/Figure-1-4.jpg\" width=\"2360\" height=\"1158\" \/><\/p>\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>Currently, the company is developing a universal method for producing peptide hormones of the insulin superfamily. Synthetic Insulin New Insulin Analog Synthetic insulin with boronic acid-diol switch Palmitoyl derivative of Relaxin-2 The insulin superfamily is a large group of peptides<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false},"aioseo_notices":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>R&amp;D<\/title>\n<meta name=\"description\" content=\"peptide synthesis, relaxin-1, Insulin-like peptides\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.synpel.eu\/?page_id=9&lang=cz\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"[:en]R&amp;D[:cz]V\u00fdzkum a v\u00fdvoj - 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